Sodium Hyaluronate And Hyaluronic Acid Powder

Product Instruction

Hyaluronic acid powder Instruction

◆ Sodium hyaluronate and hyaluronic acid for skin, also known as hyaluronic acid, is a glycosaminoglycan naturally present in the body. Hyaluronic acid is an important component of the cell matrix and various tissues, and has many important physiological functions, such as: regulating cell proliferation , Migration and differentiation; natural moisturizing effect; lubricate joints to protect cartilage; regulate protein synthesis; regulate inflammation; regulate immune function; promote wound healing, etc. Hyaluronic acid's unique viscoelasticity, biocompatibility and degradability make it widely used in the field of biomedicine, including as an ophthalmic surgery assistant, anti-adhesion agent after surgery, skin wound healing regeneration assistant, drug carrier , Tissue engineering scaffold, etc.

◆ Hyaluronic acid is a white amorphous solid, odorless, highly hygroscopic, soluble in water, but insoluble in organic solvents. In the molecular structure of hyaluronic acid, the hydrophilic groups are in parallel positions of the sugar ring, and the hydrophobic hydrogen atoms form a hydrophobic region in the axial direction. Form a rigid cylindrical spiral structure in space. In aqueous solution, the molecular chain of hyaluronic acid assumes an expanded random coil structure. These hyaluronic acid chains will also entangle with each other at lower concentrations, forming a continuous three-dimensional network structure with unique rheological properties. Water molecules are fixed in the network formed by hyaluronic acid molecules through hydrogen bonding, and are not easy to be lost. Studies have shown that hyaluronic acid can absorb water about 1000 times its own weight, and is the best natural substance found in nature at present. A 1% solution can form a gel, but it easily flows under pressure and can pass through the narrow channel of the injection needle, which is a pseudoplastic material. The extraordinary rheological properties of hyaluronic acid solutions make it an ideal lubricant, capable of separating the surface of most tissues and allowing them to slide along each other.

Specification of Sodium hyaluronate/hyaluronic acid 1.2~2.0 x 10⁶Da Cosmetical grade

Product benefits

1.Improve joint function

2.Natural moisturizing lubricant

3. Prevent the occurrence of arteriosclerosis, pulse disturbance and brain atrophy.

Side effects

1. Occasionally urticaria, dermatitis, pruritus should be discontinued and treated appropriately.

2. Sometimes there is pain, swelling, blocking the penetration of water flow, and occasionally edema, redness, heat, and local pressure.

Application of Sodium hyaluronate and hyaluronic acid powder

1. Sodium hyaluronate and hyaluronic acid for skin is highly hygroscopic. Its primary role in the human body is structural support and moisturizing. It provides lubrication and shock absorption for cells and other extracellular matrix components (including collagen and elastin), while regulating The water balance of the tissue provides a convenient environment for cell migration and value addition. There are also a large number of negatively charged carboxyl groups on the hyaluronic acid skeleton, which plays a role of ion exchange and can adjust the concentration of cations around the cell.

2. In addition, hyaluronic acid also acts as a signaling molecule, and participates in cell signaling and regulates various cell activities by binding to a variety of protein receptors on the extracellular matrix and cell membrane, including cell proliferation, migration, and differentiation , Adhesive, etc., thereby regulating the body's physiological functions, such as hyaluronic acid can promote the aggregation of leukocytes at the site of inflammation by binding to the CD44 receptor, thereby promoting the body's immune anti-inflammatory effect.

3. This signal regulation effect of hyaluronic acid is related to its molecular weight, and hyaluronic acid of different molecular weight triggers different signal pathways. High-molecular-weight hyaluronic acid exhibits anti-angiogenesis, scarring and anti-inflammatory effects, while low-molecular-weight hyaluronic acid (<100kDa), on the contrary, exhibits pro-inflammatory, immunostimulatory, promotes scar formation and angiogenesis The role. The cause of this difference is currently inconclusive,

Product Source:

1. Animal tissue: The main raw materials are chicken crowns and bull's eye vitreous, etc. The raw materials are degreased and dehydrated with acetone or ethanol, soaked with distilled water, filtered, and then treated with sodium chloride aqueous solution and chloroform solution, and then mixed with trypsin to obtain a mixed solution. Finally, the refined hyaluronic acid was treated and purified with an ion exchanger. This method has extremely low extraction rate, only about 1%, and the separation process is complicated, making the hyaluronic acid expensive, reaching $ 5,000 / kg, which limits the Used in large quantities in cosmetics.

2.Microbial fermentation: using glucose as a carbon source fermentation broth. Fermentation in the culture medium for 48 hours. After the fermentation is completed, the mycelia and impurities are removed by filtration, and then simple operations such as alcohol precipitation are used to obtain high-purity products. Fermentation The advantage of hyaluronic acid produced by the method is that the molecular weight can be set according to the design of the product. The key of the fermentation method is the selection of strains, and most of them use streptococcus and lactic acid bacteria.

3. Chemical synthesis: using natural enzyme polymerization; firstly use polysaccharide polymer to synthesize "hyaluronic acid oxazepine derivative", then add hydrolytic enzyme to make a complex of derivative and enzyme, and finally Hyaluronic acid is synthesized by removing the enzyme from the 90 ° C reaction solution. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.

Flow chart of Sodium hyaluronate

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