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•Product name: L-methylfolate calcium
•Also known as: L-5-MTHF-Ca
•Product code: YG-PA039
•L-methylfolate calcium CAS No.: 151533-22-1
•Molecular Formula: C20H23CaN7O6
•Certifications: ISO, HACCP, CQC, KOSHER, HALAL
•Specification: L-methylfolate calcium USP
Product Instruction
Product Instruction
◆ Methyltetrahydrofolate Calcium, L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
◆ It goes by several other common names including:
Methylfolate
L-5-Methyltetrahydrofolic acid(refers to the calcium salt molecule it is attached to)
Metafolin and Deplin
5-MTHF and L-5-MTHF (in this article 5-MTHF refers to L-5-MTHF)
Levomefolic acid
5-methyltetrahydrofolate
(6S)-5-methyltetrahydrofolate and Quatrefolic
◆ L-5-Methyltetrahydrofolate (L-5-MTHF) is a new type of folic acid medicine, which is gradually applied to medicines and foods. At present, this ingredient has become a new type of vitamin health care product on the international market. It can be used as a food additive and the main ingredient of some nutrition and health products, without any side effects, but also has good efficacy and function.
◆ This ingredient has become a multi-functional medicine with medical treatment, health care and prevention. It can participate in the metabolism of amino acids and the biosynthesis of nucleotides. It is a type of essential organic substance that maintains the normal life process of the organism. Folic acid has the functions of preventing tumors, megaloblastic anemia of neural tube defects and cardiovascular diseases.
Specification of L-Methyltetrahydrofolate Calcium USP
ITEMS | SPECIFICATIONS | METHOD |
Characters | Powder | Organoleptic |
Appearance | White to light yellowish crystalline powder | Organoleptic |
Solubility
| Sparingly soluble in water and very slightly soluble or insoluble in most organic solvents; soluble in alkaline solutions |
In-House |
Loss on drying | 6.0%~17.0% | Karl Fischer |
Calcium (anhydrous basis) | 7.0%~8.5% | -- |
Bulk density | 0.5~0.6g/ml | -- |
Identification: | HPLC/TLC | |
A. Infrared absorption | -- | |
B. Test of calcium | -- | |
C. Retention time (HPLC) | -- | |
Assay (anhydrous solvent-free basis) | 95.0%~102.0% | HPLC |
D-5-Methylfolate | ≤1.0% | -- |
Impurities | ||
Chloride | ≤0.5% | -- |
Heavy Metals | ≤10ppm | -- |
As | ≤1.5ppm | -- |
Pb | ≤1.0ppm | -- |
Hg | ≤0.1ppm | -- |
Cd | ≤0.5ppm | -- |
Residual solvents | ||
Ethanol | ≤0.5% | -- |
2-Propanol | ≤0.5% | -- |
Microbiological | ||
Total Plate Count | 1000cfu/g Max | -- |
Yeast& Mold | 100cfu/g Max | -- |
E.Coli colonies/g | Negative (-) | -- |
Mites /g | Negative (-) | -- |
Methyltetrahydrofolate Calcium Benefits
◆ Major depressive disorder
Preliminary research suggests that levomefolic acid taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication.
◆ Diabetic neuropathy
Early studies show L-Methyltetrahydrofolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.
◆ Supplementing Calcium levomefolate is the clear alternative while pregnant.
Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.
◆ Cardiovascular disease and cancer
L-Glutamicacid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.
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